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      The Morphologic Basis of Proteinuria in Experimental Chronic Serum Sickness Glomerulonephritis

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      S. Karger AG

      Serum sickness, Proteinuria, Tracers

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          The morphologic basis of proteinuria in experimental chronic serum sickness glomerulonephritis in rabbits was studied by light and electron microscopy using horseradish peroxidase (effective radius 30 Å; mol. wt. 40,000) and ferritin (effective radius 60 Å; mol. wt. 480,000) as protein tracers. It was found that more ferritin, but paradoxically, less horseradish peroxidase gained access to the urinary space. Observations made by electron microscopy appeared to indicate a decreased permeability of most part of the damaged glomerular capillary wall to both tracers. These results favor the interpretation that proteinuria in chronic serum sickness glomerulonephritis is the result of focal rather than diffuse increase in permeability of the glomerular capillary wall. Lesions of segments of the nephron other than the glomerular capillary wall, may contribute to the leakage of proteins to the urinary space.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 20
          : 6
          : 316-335
          Departments of Pathology, Microbiology and Medicine, State University of New York, School of Medicine, Buffalo, N.Y.
          181260 Nephron 1978;20:316–335
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 20
          Original Paper

          Cardiovascular Medicine, Nephrology

          Tracers, Serum sickness, Proteinuria


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