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      Dynamic changes in hair cell ribbon synapse induced by loss of spiral ganglion neurons in mice.

      1 , 2

      Chinese medical journal

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          Abstract

          Previous studies have suggested that primary degeneration of hair cells causes secondary degeneration of spiral ganglion neurons (SGNs), but the effect of SGN degeneration on hair cells has not been studied. In the adult mouse inner ear ouabain can selectively and permanently induce the degeneration of type 1 SGNs while leaving type 2 SGNs, efferent fibers, and sensory hair cells relatively intact. This study aimed to investigate the dynamic changes in hair cell ribbon synapse induced by loss of SGNs using ouabain application to the round window niche of adult mice.

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          Author and article information

          Journal
          Chin. Med. J.
          Chinese medical journal
          0366-6999
          0366-6999
          2014
          : 127
          : 10
          Affiliations
          [1 ] Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 200031, China; Department of Otolaryngology, MEEI, Harvard Medical School, Boston, MA 02115, USA.
          [2 ] Department of Otolaryngology, Eye, Ear, Nose & Throat Hospital, Fudan University, Shanghai 200031, China. Email: chifanglu@126.com.
          Article
          24824260

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