+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Selective Blockade of Catecholaminergic Alpha and Beta Receptors on Histamine-Induced Release of Corticotropin and Prolactin

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          We investigated the role of adrenergic receptors in histamine (HA)-induced release of corticotropin (ACTH) and prolactin (PRL) in conscious male rats. Specific α- or β-receptor antagonists were administered intracerebroventricularly in doses of 1 mmol at time –20 min, and HA (270 nmol), the H<sub>1</sub> receptor agonist 2-thiazolylethylamine (2-TEA; 2,180 nmol) or the H<sub>2</sub> receptor agonist 4-methylHA (4-MeHA; 790 nmol) were administered intracerebroventricularly at –15 min. The animals were decapitated at 0 min, and plasma was analyzed for ACTH and PRL. Administration of HA and the histaminergic agonists stimulated ACTH secretion equally, while only HA and the H<sub>2</sub> receptor agonist stimulated PRL secretion. Pretreatment with the adrenergic receptor antagonists had no effect on the ACTH response to the histaminergic compounds. In contrast, the PRL response to HA or 4-MeHA was inhibited or prevented by the α-receptor antagonists phenoxybenzamine and phentolamine, the α<sub>1</sub>-receptor antagonist prazocin, the β-receptor antagonist propranolol and the β<sub>1</sub>-receptor antagonist atenolol, whereas the α<sub>2</sub>-receptor antagonist yohimbine or the β<sub>2</sub>-receptor antagonist ICI-118-551 had no effect. The study indicates that histaminergic neurons interact with the catecholaminergic neuronal system in regulation of PRL secretion, and that this interaction is dependent upon activation of α<sub>1</sub>- and β<sub>1</sub>-receptors. In contrast, histaminergic neurons stimulate ACTH secretion independently of adrenergic receptor activation.

          Related collections

          Most cited references 6

          • Record: found
          • Abstract: not found
          • Article: not found

          Histamine-immunoreactive nerve fibers in the rat brain

            • Record: found
            • Abstract: not found
            • Article: not found

            Histaminergic neuron system in the brain: Distribution and possible functions

              • Record: found
              • Abstract: not found
              • Article: not found

              Prolactin (PRL) release-inhibiting properties of the α2 adrenergic receptor antagonist Idazoxan: Comparison with yohimbine


                Author and article information

                S. Karger AG
                May 1999
                20 May 1999
                : 69
                : 5
                : 309-315
                Department of Medical Physiology, Division of Endocrinology and Metabolism, The Panum Institute and Department of Surgery C, Rigshospitalet, University of Copenhagen, Denmark
                54432 Neuroendocrinology 1999;69:309–315
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 4, Tables: 1, References: 52, Pages: 7
                Regulation of Corticotropin and Adrenal Steroid Feed-Back


                Comment on this article