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      Towards mild metal-catalyzed C-H bond activation.

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          Abstract

          Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C-H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references).

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          Author and article information

          Journal
          Chem Soc Rev
          Chemical Society reviews
          Royal Society of Chemistry (RSC)
          1460-4744
          0306-0012
          Sep 2011
          : 40
          : 9
          Affiliations
          [1 ] Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
          Article
          10.1039/c1cs15083a
          21666903
          a5062f29-cb4b-4bd3-be79-ed484d9bf38b
          This journal is © The Royal Society of Chemistry 2011
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