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      SOD/catalase mimetic platinum nanoparticles inhibit heat-induced apoptosis in human lymphoma U937 and HH cells.

      Free Radical Research

      Acrylic Resins, Antineoplastic Agents, chemistry, pharmacology, Apoptosis, drug effects, Blotting, Western, Caspase 3, metabolism, Catalase, Cell Line, Tumor, DNA Fragmentation, Flow Cytometry, Free Radical Scavengers, Hot Temperature, Humans, Lymphoma, Nanoparticles, Peroxides, Platinum, therapeutic use, Reactive Oxygen Species, Superoxide Dismutase, Superoxides, U937 Cells

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          Abstract

          Platinum nanoparticles (Pt-NPs) are known to possess anti-tumouric activity and the ability to scavenge superoxides and peroxides indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. These potentials seem useful in the protection and/or amelioration of oxidative stress-associated pathologies, but, when they are combined with a therapeutic modality that depends upon the mediation of reactive oxygen species in cell killing induction, the effect of Pt-NPs might be questionable. Here, the effects of polyacrylic acid-capped Pt-NPs (nano-Pts) on hyperthermia (HT)-induced apoptosis and the underlying molecular mechanisms were investigated in human myelomonocytic lymphoma U937 and human cutaneous T-cell lymphoma HH cells. The results showed that the pre-treatment with nano-Pts significantly inhibited HT-induced apoptosis in a dose-dependent manner. Superoxide, but not peroxides, was suppressed to varying extents. All pathways involved in apoptosis execution were also negatively affected. The results reveal that the combination of nano-Pts and HT could result in HT-desensitization.

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          Journal
          21047173
          10.3109/10715762.2010.532494

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