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      Regulation of thermogenic capacity in brown and white adipocytes by the prebiotic high-esterified pectin and its postbiotic acetate.

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          Abstract

          High-esterified pectin (HEP) is a prebiotic able to modulate gut microbiota, associated with health-promoting metabolic effects in glucose and lipid metabolism and adipostatic hormone sensitivity. Possible effects regulating adaptive thermogenesis and energy waste are poorly known. Therefore, we aimed to study how physiological supplementation with HEP is able to affect microbiota, energy metabolism and adaptive thermogenic capacity, and to contribute to the healthier phenotype promoted by HEP supplementation, as previously shown. We also attempted to decipher some of the mechanisms involved in the HEP effects, including in vitro experiments.

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          Author and article information

          Journal
          Int J Obes (Lond)
          International journal of obesity (2005)
          Springer Science and Business Media LLC
          1476-5497
          0307-0565
          March 2020
          : 44
          : 3
          Affiliations
          [1 ] Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB) and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Palma de Mallorca, 07122, Spain.
          [2 ] Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558, Nuthetal, Germany.
          [3 ] The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91, Stockholm, Sweden.
          [4 ] Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain.
          [5 ] Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands (UIB) and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Palma de Mallorca, 07122, Spain. amrodriguez@uib.es.
          [6 ] Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain. amrodriguez@uib.es.
          Article
          10.1038/s41366-019-0445-6
          10.1038/s41366-019-0445-6
          31467421
          a5094219-4f7a-41ec-bd27-8c0948c5bf78
          History

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