Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.

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Abstract

Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations.

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Author and article information

Journal

Journal ID (iso-abbrev): Biol. Psychiatry

Title: Biological psychiatry

ISSN (Electronic): 1873-2402

ISSN (Print): 0006-3223

Publication date (Electronic): Mar 1 2016

Volume: 79

Issue: 5

Affiliations

[1 ] Applied Human Molecular Genetics, Kennedy Center, Department of Clinical Genetics, Copenhagen University Hospital, Rigshospitalet, Glostrup; Denmark.

[2 ] deCODE Genetics, Reykjavik, Iceland.

[3 ] Department of Human Genetics, University Medicine, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

[4 ] Department of Pediatrics, Tourette Clinic, Herlev Hospital, Herlev.

[5 ] Institute of Biological Psychiatry, Mental Health Centre, Sct. Hans, Mental Health Services, Capital Region of Denmark, Hillerød; Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen; iPSYCH-The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark.

[6 ] Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece.

[7 ] Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.

[8 ] Vadaskert Child and Adolescent Psychiatry Clinic, Semmelweis University, Budapest, Hungary.

[9 ] Section of Child Neuropsychiatry, Department of Medical and Pediatric Sciences, Catania University, Catania, Italy.

[10 ] Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University, Halle, Germany.

[11 ] Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.

[12 ] Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona, Verona, Italy.

[13 ] Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland.

[14 ] Department of Clinical and Health Psychology, Utrecht University & Altrecht Academic Anxiety Outpatient Clinics, Utrecht.

[15 ] Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

[16 ] Clinic of Psychiatry, Social Psychiatry and Psychotherapy, and Institute of Human Genetics, Hannover Medical School, Hannover, Germany.

[17 ] Wilhelm Johansen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

[18 ] Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

[19 ] Vadaskert Child and Adolescent Psychiatry Clinic, Semmelweis University, Budapest, Hungary. Electronic address: zeynep.tumer@regionh.dk.