Renin Disappearance Rate in Puppies

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Abstract

The disappearance rate of endogenous renin from the circulating blood after bilateral nephrectomy was studied in 4 puppies aged 16–21 days. Mean half-times of the fast and slow component of the disappearance curves of renin were 9.15 min ± 0.87 (SD) and 84.0 min ± 16.8 (SD), respectively. These values are not different from the values reported for adult dogs in the literature. The metabolic degradation of renin is not different between young and adult dogs and does not contribute to the elevated plasma renin activity in the puppy.

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Author and article information

Journal

Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1984

Publication date (Print): 1984

Publication date (Electronic): 26 November 2008

Volume: 20

Issue: 3

Pages: 197-201

Affiliations

^aDepartment of Pediatrics, University of Nijmegen, The Netherlands; ^b Nephrological Division, Department of Medicine, University Hospital of Ghent, Belgium

Article

Publisher ID: 179996 Other ID: Horm Res 1984;20:197–201

DOI: 10.1159/000179996

PubMed ID: 6386648

SO-VID: a5382570-4689-4305-b713-e5e92c3154ff

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 11 October 1983

Date accepted : 11 April 1984

Page count

Pages: 5

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