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      Central Nervous System Control of Thyrotropin Secretion during Sleep and Wakefulness

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          Abstract

          Thyrotropin (TSH) is a pulsatile secreted hormone with a pronounced circadian rhythmicity and a characteristic nightly surge based on an augmentation of pulsatile release. A number of physiological factors influence TSH secretion via an alteration in the amount of pulsatile released hormone. An increase in somatostatinergic tone during fasting appears to decrease TSH pulse amplitude and sequentially mean TSH serum levels. In contrast, blockade of dopaminergic tone by metoclopramide infusion when circulating TSH levels are low during the afternoon hours increase TSH pulse amplitude to levels comparable to the nightly TSH surge suggesting a physiological dampening of TSH pulse amplitude by dopamine during the daytime.

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          Physiological regulation of thyrotropin

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              Author and article information

              Journal
              HRE
              Horm Res Paediatr
              10.1159/issn.1663-2818
              Hormone Research in Paediatrics
              S. Karger AG
              978-3-8055-6666-7
              978-3-318-00288-1
              1663-2818
              1663-2826
              1998
              March 1998
              16 March 1998
              : 49
              : 3-4
              : 173-177
              Affiliations
              Department of Clinical Endocrinology, Medizinische Hochschule, Hannover, Germany
              Article
              23167 Horm Res 1998;49:173–177
              10.1159/000023167
              9550121
              © 1998 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 2, References: 42, Pages: 5
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