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Haematuria is a marker for the severity of acute kidney injury but does not associate with thrombocytopenia in acute Puumala hantavirus infection.
Tuula K Outinen
1 ,
Paula Mantula
1 ,
Outi K Laine
1
,
2 ,
Ilkka Pörsti
1
,
2 ,
Antti Vaheri
3 ,
Satu M Mäkelä
1
,
2 ,
Jukka Mustonen
1
,
2
August 2 2017
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Abstract
Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome characterized by thrombocytopenia, capillary leakage and acute kidney injury (AKI) with proteinuria and haematuria. Although the typical histologic lesion is acute tubulointerstitial nephritis, the amount of glomerular proteinuria predicts the severity of upcoming AKI. Here, we studied the associations of haematuria and proteinuria with the severity of emerging AKI, thrombocytopenia and markers of coagulation and fibrinolysis in PUUV infection.