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      Effects of Growth Hormone and Insulin-Like Growth Factor I on Muscle in Mouse Models of Human Growth Disorders

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          The precise effects of growth hormone (GH) and insulin-like growth factor I (IGF-I) on muscle development and physiology are relatively unknown. Furthermore, there have been conflicting reports on the effects of GH/IGF-I on muscle. Distinguishing the direct effects of GH versus those of IGF-I is problematic, but animal models with altered GH/IGF-I action could help to alleviate some of the conflicting results and help to determine the independent actions of GH and IGF-I. The phenotypes of several mouse models, namely the GH receptor-gene-disrupted (GHR –/–) mouse and a variety of IGF-I –/– mice, are summarized, which ultimately will aid our understanding of this complex area.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          January 2007
          09 July 2008
          : 66
          : Suppl 1
          : 26-34
          aEdison Biotechnology Institute and bDepartment of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
          96620 Horm Res 2006;66:26–34
          © 2006 S. Karger AG, Basel

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          Page count
          Figures: 1, References: 90, Pages: 9
          The Experimental Basis for the Role of an Interaction between the Muscle and GH/IGF Systems


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