Effects of Growth Hormone and Insulin-Like Growth Factor I on Muscle in Mouse Models of Human Growth Disorders

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Abstract

The precise effects of growth hormone (GH) and insulin-like growth factor I (IGF-I) on muscle development and physiology are relatively unknown. Furthermore, there have been conflicting reports on the effects of GH/IGF-I on muscle. Distinguishing the direct effects of GH versus those of IGF-I is problematic, but animal models with altered GH/IGF-I action could help to alleviate some of the conflicting results and help to determine the independent actions of GH and IGF-I. The phenotypes of several mouse models, namely the GH receptor-gene-disrupted (GHR –/–) mouse and a variety of IGF-I –/– mice, are summarized, which ultimately will aid our understanding of this complex area.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISBN: 978-3-8055-8244-5

ISBN: 978-3-318-01440-2

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 2006

Publication date (Print): January 2007

Publication date (Electronic): 09 July 2008

Volume: 66

Issue: Suppl 1

Pages: 26-34

Affiliations

^aEdison Biotechnology Institute and ^bDepartment of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA

Article

Publisher ID: 96620 Other ID: Horm Res 2006;66:26–34

DOI: 10.1159/000096620

PubMed ID: 17259718

SO-VID: a55a898e-c6da-44fb-ac7a-46161ba4868b

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Effects of Growth Hormone and Insulin-Like Growth Factor I on Muscle in Mouse Models of Human Growth Disorders

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Karger: Endocrinology

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