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      Application of multiple imputation using the two-fold fully conditional specification algorithm in longitudinal clinical data.

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          Abstract

          Electronic health records of longitudinal clinical data are a valuable resource for health care research. One obstacle of using databases of health records in epidemiological analyses is that general practitioners mainly record data if they are clinically relevant. We can use existing methods to handle missing data, such as multiple imputation (mi), if we treat the unavailability of measurements as a missing-data problem. Most software implementations of MI do not take account of the longitudinal and dynamic structure of the data and are difficult to implement in large databases with millions of individuals and long follow-up. Nevalainen, Kenward, and Virtanen (2009, Statistics in Medicine 28: 3657-3669) proposed the two-fold fully conditional specification algorithm to impute missing data in longitudinal data. It imputes missing values at a given time point, conditional on information at the same time point and immediately adjacent time points. In this article, we describe a new command, twofold, that implements the two-fold fully conditional specification algorithm. It is extended to accommodate MI of longitudinal clinical records in large databases.

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          Author and article information

          Journal
          Stata J
          The Stata journal
          1536-867X
          1536-867X
          Apr 01 2014
          : 14
          : 2
          Affiliations
          [1 ] University College London, London, uk, catherine.welch@ucl.ac.uk.
          [2 ] London School of Hygiene & Tropical Medicine, London, uk, jonathan.bartlett@lshtm.ac.uk.
          [3 ] University College London, London, UK, i.petersen@ucl.ac.uk.
          Article
          EMS59483
          4124036
          25420071

          longitudinal data, multiple imputation, st0345, twofold

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