The publication of several series of theological commentaries since the year 2000 marked the entrance of the discipline Theological interpretation of the Bible on the hermeneutical front. A lack of well-developed methodological considerations, underlying the practice of Theological interpretation of the Bible has, however, handicapped the theological interpretation of Bible texts. It is the aim of this article to contribute to the development thereof. Three meta-hermeneutical aspects that make up the broad methodological foundation of Theological interpretation of the Bible, namely metaphysics, epistemology and ethics are explored.