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      Effects of Renal Arterial Endothelin-1 and Endogenous Endothelins on Regional Kidney Blood Flow and Renal Antihypertensive Mechanisms in Anesthetized Rabbits

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          To determine how endothelins affect regional kidney blood flow and responses to increased renal artery pressure (RAP), an extracorporeal circuit was established to control RAP independent of the mean systemic arterial pressure (MAP). RAP was first set at ∼65 mm Hg, and endothelin-1 (1 ng/kg/min for 30 min then 0.4 ng/kg/min) or vehicle was infused into the renal artery, or the ET<sub>A</sub>/ET<sub>B</sub> antagonist TAK-044 (3 mg/kg plus 3 mg/kg/h) or vehicle was administered intravenously. RAP was then progressively increased in steps from ∼65 to ∼160 mm Hg. When RAP was ∼65 mm Hg, endothelin-1 increased renal vascular resistance (RVR, 72%), and reduced cortical (CBF, 26%) but not medullary blood flow (MBF). TAK-044 reduced MAP (12%) and RVR (15%) and increased CBF (21%) but not MBF. When RAP was increased, renal blood flow (RBF), glomerular filtration rate, and urine and sodium excretion increased, while MAP fell. These responses were unaffected by endothelin-1. TAK-044 potentiated the increases in RBF and reductions in MAP in response to increased RAP, but did not affect urine and sodium excretion. Plasma renin activity was reduced by endothelin-1 and increased by TAK-044. Thus, both exogenous and endogenous endothelins reduce CBF but not MBF, and reduce plasma renin activity, but neither affect pressure natriuresis.

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          Effects of endothelin on renal regional blood flow in dogs

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            Renal haemodynamic effects of endothelin-1 and the ETA/ETB antagonist TAK-044 in anaesthetized rabbits

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              Effect of endothelin blockade on pressure natriuresis in nitric oxide-deficient hypertensive rats


                Author and article information

                Kidney Blood Press Res
                Kidney and Blood Pressure Research
                S. Karger AG
                02 November 2000
                : 23
                : 6
                : 366-375
                aDepartment of Physiology, Monash University, Clayton, Vic., Australia, and bDepartment of Physiology, Institute of Physiology and Pharmacology, University of Göteborg, Sweden
                25985 Kidney Blood Press Res 2000;23:366–375
                © 2000 S. Karger AG, Basel

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                Page count
                Figures: 6, Tables: 1, References: 34, Pages: 10
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/25985
                Original Paper


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