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      Lipid peroxidation, thiol groups, and total antioxidant capacity in mothers in natural vaginal delivery with and without Entonox: A cohort study


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          Background and objectives

          Considering that very few studies have been conducted on the effect of Entonox on oxidative stress markers, this study was conducted to compare these markers in natural vaginal delivery (NVD) with and without Entonox.

          Materials and methods

          The present cohort study was conducted on 120 women in maternity wards divided into two groups, including an NVD group with and an NVD group without Entonox. After obtaining the mothers’ written consent, 5 cc of venous blood was taken at the end of their second stage of labor for lipid peroxidation, thiol groups, and total antioxidant capacity tests. The data obtained were analyzed using descriptive (mean) and inferential ( t-test) statistics.


          Lipid peroxide was 6.267 ± 5.39 in NVD without Entonox and 5.12 ± 3.89 in NVD with Entonox, suggesting the lack of a statistically significant difference ( p = 0.191). Thiol marker was 0.34 ± 0.26 in NVD without and 0.26 ± 0.24 in NVD with Entonox, suggesting the lack of a statistically significant difference ( p = 0.09).The FRAP results were 0.936 ± 0.696 in NVD without and 1.21 ± 0.89 in NVD with Entonox, suggesting the lack of a statistically significant difference ( p = 0.06).


          Entonox can be safely used in NVD without increasing the risk of oxidative stress.

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          Most cited references17

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          Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration.

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            Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.

            K Satoh (1978)
            A new colorimetric method for quantitative analysis of serum lipid peroxide, free of interference from sialic acids, has been developed. We have used the thiobarbituric acid dissolved in sodium sulfate solution and both liberation of lipid peroxide and color reaction have been performed simultaneously by heating serum protein precipitate with this reagent in a weak acid solution. The new method is specific and facilitates the precise measurements of serum lipid peroxide. The average values determined by the new method increased slightly with age in healthy subjects. In patients with sequelae of cerebrovascular disorders, serum lipid peroxide values were higher than in healthy controls. These results may demonstrate the important role of lipid peroxide in aging and cerebrovascular disorders.
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              Nitrous oxide for labor analgesia: expanding analgesic options for women in the United States.

              Nitrous oxide (N2O) is a commonly used labor analgesic in many Western countries, but is used infrequently in the United States. The University of California at San Francisco has been offering N2O for labor analgesia for more than 30 years. Vanderbilt University Medical Center recently began offering N2O as an option for pain relief in laboring women. Many women report that N2O provides effective pain relief during labor and argue that it should be made more widely available in the United States. This article discusses the use of N2O for pain management during labor, including its history, properties, clinical indications, and use and environmental safety issues. Practical issues regarding implementation of N2O service in a medical center setting are also discussed.

                Author and article information

                Interventional Medicine and Applied Science
                Akadémiai Kiadó (Budapest )
                26 October 2018
                December 2018
                : 10
                : 4
                : 207-209
                [ 1 ]Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences , Hamadan, Iran
                [ 2 ]Medical School, Arak University of Medical Sciences , Arak, Iran
                Author notes
                [* ]Corresponding author: Katayon Vakilian, PhD; Medical School, Arak University of Medical Sciences, Peiambar Azam Campus, Sardasht, P.O. Box: 3848176941, Arak, Iran; Phone: +98 91 2324 9840; Fax: +98 34 173 524; E-mail: dr.kvakilian@ 123456arakmu.ac.ir
                © 2018 The Author(s)

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.

                : 04 April 2018
                : 06 July 2018
                Page count
                Figures: 0, Tables: 1, Equations: 0, References: 15, Pages: 3
                Funding sources: Financial support was received by Arak University of Medical sciences by cod: 154.
                ORIGINAL PAPER

                Medicine,Immunology,Health & Social care,Microbiology & Virology,Infectious disease & Microbiology
                women,oxidative stress,Entonox,natural vaginal delivery,total antioxidant capacity,lipid peroxidation


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