Comparison of the effect of screening test for different tuberculin dosage forms for close contacts of tuberculosis in colleges and universities in Nanning

Abstract

Objective To understand the similarities and differences in different dosage forms of tuberculin test for college students having close contact with tuberculosis in Nanning colleges and universities in order to provide reference for the prevention and control of tuberculosis.

Methods A total of 7 771 students were screened for symptoms and tuberculin skin test (TST), X radiographs from 2018 to 2019 in Nanning. The used doses of Purified Protein Derivative of Tuberculin (TB-PPD) in 2018 and 2019 were 2 IU and 5 IU respectively.

Results A total of 916 positive cases were detected in 2 years, with the total positive rate of 11.79%. Total strong positive number was 184 and the strong positive rate was 2.37%. The number of tuberculosis patients was 17. Positive rate of the students from grade one to grade four was 13.88%, 8.57%, 10.59%, 10.29%, respectively. The difference was statistically significant (χ ² =46.30, P<0.01). The positive rates of male and female in the past two years were 13.24%(500/3 777) and 10.42%(416 /3 994), respectively (χ ² = 17.84, P<0.01), and there was no significant difference in the diagnosis of pulmonary tuberculosis among TST positive patients (χ ² = 0. 29, P = 0. 59). The positive and strong positive rates of 2 IU dose and 5 IU dose were 7.57%, 15.04%, respectively, the difference in dosage forms were statistically significant (χ ² = 114.41, P<0.01). The tuberculosis case detection rate (CDR) of moderate & above positive subjects of 2 IU and 5 IU dose was 6.92% and 2.07%, respectively, the difference was statistically significant (χ ² = 6.60, P = 0.02).

Conclusion More positive tuberculosis cases (including moderate & strong positive) can be detected by using 5 IU dose, though it is may not have advantage over discovering tuberculosis patients comparing to 2 IU dose. However, it is more critical to minimize the following cases and control the outbreak in university.

Abstract

【摘要】 目的 了解南宁市高校肺结核密切接触者结核菌素试验使用不同剂型筛查效果的异同, 为高校结核病防控工作 提供依据。 方法 南宁市高校 2018—2019 年共 7 771 名筛查对象同时进行症状、结核菌素皮肤试验 (TST)、X线胸片筛查 及结果分析, 2018、2019 年TST分别使用 2IU、5IU 结核菌素纯蛋白衍生物 (TB-PPD) 试剂。 结果 两年共检出阳性人数 916 例, 总阳性率 11.79%; 强阳性人数 184 例, 强阳性率 2.37%, 共检出肺结核患者 17 例。大学一至四年级阳性率分别为 13.88%, 8.57%, 10.59%, 10.29%, 差异有统计学意义 (χ ² = 46.30, P<0.01)。两年男、女生总阳性率分别为 13.24% (500/3 777), 10.42% (416/3 994), 差异有统计学意义 (χ ² = 17.84, P<0.01); 不同性别TST中度以上阳性者肺结核检出率差 异无统计学意义 (χ ² = 0.29, P = 0.59)。不同剂型比较, 2IU、5IU 剂型阳性检出率分别为 7.57% 及 15.04%, 差异有统计学意 义 (χ ² = 114.41, P<0.01)。2 IU、5 IU 剂型 TST 中度以上阳性者肺结核检出率分别为 6.92% 和 2.07%, 差异有统计学意义 (χ ² = 6.60, P = 0.02)。 结论 使用 5 IU 剂型可以发现更多的阳性者(含中度阳性、强阳性); 5 IU 剂型可能对于发现肺结核患 者与 2 IU 剂型比较无优势, 但是在减少续发病例控制学校疫情方面意义更重大。