Social Entrepreneurship for Sexual Health (SESH): A New Approach for Enabling Delivery of Sexual Health Services among Most-at-Risk Populations

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Abstract

Joseph Tucker and colleagues argue for social entrepreneurship, a new approach to help improve delivery of sexual health services.

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Most cited references 51

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Prevention of HIV-1 infection with early antiretroviral therapy.

Myron S Cohen, Ying Q Chen, Marybeth McCauley … (2011)

Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1-infected subjects with CD4 counts between 350 and 550 cells per cubic millimeter were randomly assigned in a 1:1 ratio to receive antiretroviral therapy either immediately (early therapy) or after a decline in the CD4 count or the onset of HIV-1-related symptoms (delayed therapy). The primary prevention end point was linked HIV-1 transmission in HIV-1-negative partners. The primary clinical end point was the earliest occurrence of pulmonary tuberculosis, severe bacterial infection, a World Health Organization stage 4 event, or death. As of February 21, 2011, a total of 39 HIV-1 transmissions were observed (incidence rate, 1.2 per 100 person-years; 95% confidence interval [CI], 0.9 to 1.7); of these, 28 were virologically linked to the infected partner (incidence rate, 0.9 per 100 person-years, 95% CI, 0.6 to 1.3). Of the 28 linked transmissions, only 1 occurred in the early-therapy group (hazard ratio, 0.04; 95% CI, 0.01 to 0.27; P<0.001). Subjects receiving early therapy had fewer treatment end points (hazard ratio, 0.59; 95% CI, 0.40 to 0.88; P=0.01). The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.).

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Social entrepreneurship research: A source of explanation, prediction, and delight

Ignasi Martí, Johanna Mair (2006)

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Is Open Access

Defining Research to Improve Health Systems

Jan H. F. Remme, Taghreed Adam, Francisco Becerra-Posada … (2010)

Robert Terry and colleagues present working definitions of operational research, implementation research, and health systems research within the context of research to strengthen health systems.

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Author and article information

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Journal ID (nlm-ta): PLoS Med

Journal ID (iso-abbrev): PLoS Med

Journal ID (publisher-id): PLoS

Journal ID (pmc): plosmed

Title: PLoS Medicine

Publisher: Public Library of Science (San Francisco, USA )

ISSN (Print): 1549-1277

ISSN (Electronic): 1549-1676

Publication date Collection: July 2012

Publication date (Print): July 2012

Publication date (Electronic): 17 July 2012

Volume: 9

Issue: 7

Electronic Location Identifier: e1001266

Affiliations

[1 ]University of North Carolina Project-China, Guangzhou, China

[2 ]Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, United States of America

[3 ]Clinical Research Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom

[4 ]Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, United Kingdom

[5 ]Centre for Humanities and Medicine, Li Ka Shing Faculty of Medicine, Hong Kong University, Hong Kong

Author notes

* E-mail: joseph.tucker@ 123456post.harvard.edu

The Policy Forum allows health policy makers around the world to discuss challenges and opportunities for improving health care in their societies.

Conceived and designed the experiments: JT KF RP RWP. Analyzed the data: JT KF RP RWP. Wrote the first draft of the manuscript: JT. Contributed to the writing of the manuscript: JT KF RP RWP. ICMJE criteria for authorship read and met: JT KF RP RWP. Agree with manuscript results and conclusions: JT KF RP RWP.

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Publisher ID: PMEDICINE-D-11-02949

DOI: 10.1371/journal.pmed.1001266

PMC ID: 3398968

PubMed ID: 22815654

SO-VID: a587bd7d-a8af-4bd9-a354-516da7affe9b

Copyright © Tucker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Social Entrepreneurship for Sexual Health (SESH): A New Approach for Enabling Delivery of Sexual Health Services among Most-at-Risk Populations

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Abstract

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UCL: UN SDG 03 Good Health and Well-Being

Most cited references 51

Prevention of HIV-1 infection with early antiretroviral therapy.

Social entrepreneurship research: A source of explanation, prediction, and delight

Defining Research to Improve Health Systems

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