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      Protective Effect of Hyperbaric Oxygen on Cognitive Impairment Induced by D-Galactose in Mice.

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          Abstract

          Memory decline is characteristic of aging and age-related neurodegenerative disorders. This study was designed to investigate the protective effect of hyperbaric oxygen (HBO) against cognitive impairment induced by D-galactose (D-gal) in mice. D-gal was intraperitoneally injected into mice daily for 8 weeks to establish the aging model. HBO was simultaneously administered once daily. The results indicate that HBO significantly reversed D-gal-induced learning and memory impairments. Studies on the potential mechanisms of this action showed that HBO significantly reduced oxidative stress by increasing superoxide dismutase, glutathione peroxidase, and catalase levels, as well as the total anti-oxidation capability, while decreasing the content of malondialdehyde, nitric oxide, and nitric oxide synthase in the hippocampal CA1 region. HBO also inhibited advanced glycation end-product formation and decreased levels of tumor necrosis factor-α and interleukin-6. Moreover, HBO significantly attenuated D-gal-induced pathological injury in the hippocampus, as well as β-amyloid protein1-42 expression and retained BDNF expression. Furthermore, HBO decreased p16, p21 and p53 gene and protein expression in the hippocampus of D-gal-treated mice. In conclusion, the protective effect of HBO against D-gal-induced cognitive impairment was mainly due to its ability to reduce oxidative damage, suppress inflammatory responses, and regulate aging-related gene expression.

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          Author and article information

          Journal
          Neurochem. Res.
          Neurochemical research
          Springer Nature
          1573-6903
          0364-3190
          Nov 2016
          : 41
          : 11
          Affiliations
          [1 ] Department of Pharmacology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China.
          [2 ] Department of Neurology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China.
          [3 ] Department of Emergency, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China.
          [4 ] Department of Pharmacology, Guangxi Institute of Chinese Medicine and Pharmaceutical Science, Nanning, 530022, China.
          [5 ] Department of Hyperbaric oxygen, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, Guangxi, 530021, China.
          [6 ] Department of Hyperbaric oxygen, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Nanning, Guangxi, 530021, China. 40192385@qq.com.
          Article
          10.1007/s11064-016-2022-x
          10.1007/s11064-016-2022-x
          27485714
          a587e76d-d0b7-4c1a-a340-86b9daf75b65
          History

          Hyperbaric oxygen,Gene,D-Galactose,Cognitive impairment
          Hyperbaric oxygen, Gene, D-Galactose, Cognitive impairment

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