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      Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

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          Abstract

          The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua ( Gm-SGP) on ovariectomized (OVX) rats. After 3 months of Gm-SGP treatment, OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced, as indicated by systemic biomarkers of bone metabolism; no uterine estrogenicity was observed. Moreover, rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control group. Gm-SGP significantly decreased bone resorption-related indicators in serum. Investigation of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein levels. Further research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling pathways. It also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK, ERK, p38, and NF-κB, and ultimately suppresses the induction of c-Fos and NFATc1. Overall, these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways, thereby improving osteoporosis.

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          Author and article information

          Journal
          JOUC
          Journal of Ocean University of China
          Science Press and Springer (China )
          1672-5182
          24 August 2019
          01 October 2019
          : 18
          : 5
          : 1174-1184
          Affiliations
          1College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
          Author notes
          *Corresponding authors: WANG Jingfeng and XUE Changhu
          Article
          s11802-019-3881-y
          10.1007/s11802-019-3881-y
          Copyright © Ocean University of China, Science Press and Springer-Verlag GmbH Germany 2019.

          The copyright to this article, including any graphic elements therein (e.g. illustrations, charts, moving images), is hereby assigned for good and valuable consideration to the editorial office of Journal of Ocean University of China, Science Press and Springer effective if and when the article is accepted for publication and to the extent assignable if assignability is restricted for by applicable law or regulations (e.g. for U.S. government or crown employees).

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          Self URI (journal-page): https://www.springer.com/journal/11802

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