For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
26
views
19
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      406
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: Case report of an unusual event

      case-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The synchronous occurrence of two different neoplasias is an uncommon event, which may arise between tumors originating in the same organ or in cancer-to-cancer metastasis. We report a rare case of chronic lymphocytic leukaemia / small lymphocytic lymphoma associated with a cutaneous metastatic squamous cell carcinoma in a cervical lymph node. In the affected lymph node, it was observed an effacement of the normal architecture by neoplastic lymphocytes and it was noted the presence of neoplastic invasive epithelial islands. Immunohistochemical analysis demonstrated that lymphocytic proliferation was positive for CD20, CD5, CD23 and Kappa, and negative for CD3, CD10, Cyclin D1 and Lambda. The morphological and immunohistochemical profile lead to a phenotype of B-cell chronic lymphocytic leukaemia / small lymphocytic lymphoma. The epithelial cells were positive for CK5, thus rendering the diagnosis of synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma. Literature supports the poor prognosis in cases that present coexistence of squamous cell carcinoma and chronic lymphocytic leukaemia / small lymphocytic lymphoma. Thus, it is necessary to be aware about this unusual finding in order to provide specific treatment.

          Key words:Chronic lymphocytic leukaemia, small lymphocytic lymphoma, squamous cell carcinoma, metastasis.

          Related collections

          Most cited references19

          • Record: found
          • Abstract: not found
          • Article: not found

          Chronic lymphocytic leukemia.

          E Montserrat, C Rozman (1995)
          Article 0 comments Cited 86 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Cutaneous findings in chronic lymphocytic leukaemia.

            K L Agnew, R Ruchlemer, D Catovsky … (2004)
            Chronic lymphocytic leukaemia (CLL) is a malignancy characterized by clonal expansion of B lymphocytes with distinct morphology and immunophenotype. The dermatological literature relating to CLL is sparse. A global descriptive survey of a large number of CLL patients has not previously been published. To report the spectrum of dermatological conditions seen in a large series of CLL patients. Skin complications in patients with established CLL were identified retrospectively from clinical and photographic records, principally a database of over 750 consecutive cases. These events were classified, enumerated and compared. Forty patients with 125 skin manifestations were identified and studied. Forty-one manifestations had documented clinical or histological atypia. In 21 of these 41 complications there had been no prior immunosuppressive therapy. We observed that cutaneous malignancies frequently presented atypically both clinically and histologically. There were 18 patients with 56 instances of basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), and clinical atypia was more common with SCC than with BCC. Other cutaneous findings included varicella zoster (n = 6), leukaemia cutis (n = 3), acute graft-versus-host disease (n = 5), cutaneous drug eruptions (n = 9), multiple warts (n = 3), herpes simplex (n = 3), cutaneous T-cell lymphoma (n = 2), eosinophilic folliculitis (n = 2), malignant melanoma (n = 2) and Merkel cell tumour (n = 2). We have identified a range of dermatological conditions in CLL patients, with a tendency to atypical presentations. The atypia was independent of prior chemotherapy.
            Article 0 comments Cited 28 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Squamous cell carcinoma of head and neck in patients with well-differentiated lymphocytic lymphoma.

              D Farhi, N Perez (1987)
              Seventy-six cases of well-differentiated lymphocytic lymphoma (WDLL) were reviewed for evidence of additional malignancies. Of these, 18 patients (24%) had one to three further tumors; one half (nine) had squamous cell carcinoma (SCC). The head and neck area was the primary site in all but one case of SCC. The carcinomas were frequently multiple, recurrent, and clinically aggressive. The tumors showed unusually poor differentiation histologically. Actinic keratosis and basal cell carcinomas were frequently associated with SCC. Fifty percent metastasized to cervical lymph nodes replaced by WDLL. Lymphadenopathy due to metastatic SCC may be mistaken for malignant lymphoma alone. In two of five patients (40%), death was directly attributable to SCC. As in renal transplant recipients, SCC of the head and neck in WDLL patients is a common cause of significant complications and mortality requiring aggressive management. Immunosuppression due to WDLL and/or to chemotherapy is likely an important predisposing factor in combination with sun exposure.
              Article 0 comments Cited 9 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Clin Exp Dent
                Journal ID (iso-abbrev): J Clin Exp Dent
                Journal ID (publisher-id): Medicina Oral S.L.
                Title: Journal of Clinical and Experimental Dentistry
                Publisher: Medicina Oral S.L.
                ISSN (Electronic): 1989-5488
                Publication date (Electronic): 1 December 2015
                Publication date Collection: December 2015
                Volume: 7
                Issue: 5
                Pages: e660-e664
                Affiliations
                [1 ]DDS, MSc. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, Piracicaba, Brazil
                [2 ]DDS, PhD. Oral Pathology, School of Dentistry, Rio de Janeiro Federal University, Rio de Janeiro, Brazil
                [3 ]MD, Student. Department of Pathology, Medical Sciences Faculty, University of Campinas (UNICAMP), Tessália Vieira de Camargo, Campinas, Brazil
                [4 ]MD, PhD. Department of Pathology, Medical Sciences Faculty, University of Campinas (UNICAMP), Tessália Vieira de Camargo, Campinas, Brazil
                Author notes
                Piracicaba Dental School University of Campinas (UNICAMP) Av. Limeira 901, P.O. Box 52, 13414-903 Piracicaba, São Paulo, Brazil , E-mail: harimtavares@ 123456gmail.com
                Article
                Publisher ID: 52643
                DOI: 10.4317/jced.52643
                PMC ID: 4663071
                SO-VID: a59b44ff-a822-41ec-b392-aac60e0e469b
                Copyright © Copyright: © 2015 Medicina Oral S.L.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date accepted : 5 September 2015
                Date received : 24 June 2015
                Categories
                Subject: Case Report
                Subject: Oral Medicine and Pathology

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content406

                See all similar

                Cited by2

                See all cited by

                Most referenced authors413

                See all reference authors