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      Adverse Effect of TiO 2 Nanoparticles on Antioxidant System and Antitumor Activities of Macroalgae Gracilaria lemaneiformis

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          Abstract

          Recently, the widespread use of TiO 2 nanoparticles (nano-TiO 2) has attracted the global concern regarding their adverse effects to aquatic organisms. Nanoparticles may get to the aquatic environments and harm the growth of algae. This paper presents the studies of nano-TiO 2 concentrations influence on the photosynthetic characteristics, antioxidant system and antitumor activity of marine macroalgae Gracilaria lemaneiformis after exposed to 0, 5, 10, 20 or 40 mg L −1 of nano-TiO 2. Results showed that the photosynthetic pigment content of G. lemaneiformis obviously decreased and the antioxidant defense system was significantly disturbed after exposure to nano-TiO 2. Compared with control, the maximum level of malondialdehyde showed 3.3-fold increase for 15 days exposure to nano-TiO 2. The activity of superoxide dismutase and catalase enhanced obviously by 1.10–2.24-fold. The aqueous extract of G. lemaneiformis (AEGL) possesses anticancer activity against HepG2 liver cancer cells proliferation and the 48 h-cell inhibition exceeds 35%. But the toxicity of nano-TiO 2 would inhibit the anticancer activity of AEGL. When G. lemaneiformis was exposed to nano-TiO 2, the effect of the aqueous extract of G. lemaneiformis on the cell inhibition, reactive oxygen species production, apoptosis, cycle arrest of HepG2 cells significantly lessened, and which were linearly associated with nano-TiO 2 exposure concentration. Those results further confirmed that nano-TiO 2 can inhibit the anticancer activity of G. lemaneiformis. The results in this work imply that macroalgae can be an effective biomarker of nano-TiO 2 contaminant, and can be useful indicator to evaluate ecological effects of increasing pollutants in marine ecosystem.

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          Author and article information

          Journal
          JOUC
          Journal of Ocean University of China
          Science Press and Springer (China )
          1672-5182
          24 August 2019
          01 October 2019
          : 18
          : 5
          : 1130-1138
          Affiliations
          1Department of Chemistry, Jinan University, Guangzhou 510632, China
          2Research Center of Analysis and Test, Jinan University, Guangzhou 510632, China
          3Key Laboratory of Water/Soil Toxic Pollutants Control and Bioremediation of Guangdong Higher Education Institutes, Department of Environmental Engineering, Jinan University, Guangzhou 510632, China
          Author notes
          *Corresponding authors: YIN Pinghe and ZHAO Ling
          Article
          s11802-019-3819-4
          10.1007/s11802-019-3819-4
          Copyright © Ocean University of China, Science Press and Springer-Verlag GmbH Germany 2019.

          The copyright to this article, including any graphic elements therein (e.g. illustrations, charts, moving images), is hereby assigned for good and valuable consideration to the editorial office of Journal of Ocean University of China, Science Press and Springer effective if and when the article is accepted for publication and to the extent assignable if assignability is restricted for by applicable law or regulations (e.g. for U.S. government or crown employees).

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          Self URI (journal-page): https://www.springer.com/journal/11802

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