Effect of Various Steroids and Nonsteroidal Microsomal Enzyme Inducers upon Propoxyphene Intoxication

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Abstract

In rats, severe propoxyphene intoxication can be diminished more effectively by some catatoxic steroids than by known nonhormonal hepatic microsomal drug-metabolizing enzyme inducers, such as phenobarbital or diphenylhydantoin. Estradiol is known to exert no protective effect against most toxicants amenable to prophylaxis by catatoxic steroids, yet it is highly efficacious in preventing propoxyphene poisoning; conversely, triamcinolone and thyroxine aggravate this intoxication. (Apparently, here, resistance to an analgesic is largely dependent upon the balance between various hormones, at least when the latter are administered at very high pharmacologic dose levels.)

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1972

Publication date (Print): 1972

Publication date (Electronic): 19 March 2008

Volume: 9

Issue: 5

Pages: 316-319

Affiliations

Institut de Médecine et de Chirurgie Expérimentales, Université de Montréal, Montréal

Article

Publisher ID: 122063 Other ID: Neuroendocrinology 1972;9:316–319

DOI: 10.1159/000122063

PubMed ID: 5030044

SO-VID: a5cc4f1c-a765-4397-99ab-b3e51f93da4d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 28 December 1971

Date accepted : 08 February 1972

Page count

Pages: 4

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