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      Pulmonary thromboembolism associated with procainamide induced lupus syndrome and anticardiolipin antibodies.

      Annals of the Rheumatic Diseases
      Aged, Autoantibodies, analysis, Blood Coagulation Factors, immunology, Cardiolipins, Humans, Lupus Coagulation Inhibitor, Lupus Erythematosus, Systemic, chemically induced, complications, Male, Procainamide, adverse effects, Pulmonary Embolism, etiology

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          Abstract

          Procainamide is the commonest cause of a drug induced lupus syndrome. Long term administration of this compound may induce a variety of immunological abnormalities, including antinuclear antibodies. Uncommonly, 'lupus anticoagulants' have been demonstrated in the absence of other evidence of drug induced lupus. Details of a 67 year old man who developed not only drug induced lupus but also antiphospholipid antibodies which were associated with multiple pulmonary thromboemboli after the administration of procainamide are recorded.

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