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      Comprehensive analysis of predictive factors for rapid angiographic stenotic progression and restenosis risk in coronary artery disease patients underwent percutaneous coronary intervention with drug‐eluting stents implantation

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          Abstract

          Background

          This study aimed to explore the correlation of baseline, procedural, and postprocedure characteristics with the risk of rapid angiographic stenotic progression ( RASP) and restenosis in coronary artery disease ( CAD) patients after percutaneous coronary intervention ( PCI) with drug‐eluting stents implantation.

          Methods

          Two hundred fourteen CAD patients underwent PCI with drug‐eluting stents implantation were consecutively enrolled. Baseline, procedural, and postprocedure characteristics of patients were collected for analysis. Coronary angiography was performed to evaluate coronary stenosis before PCI and at 12 months after PCI. RASP of nontarget lesions and restenosis of stent‐implanted target lesions were then assessed.

          Results

          37.8% CAD patients occurred RASP at 12 months after PCI and compared to non‐ RASP group, RASP group presented with increased diabetes mellitus ( DM) complication, higher concentration of serum uric acid ( SUA), cardiac troponin I, N‐terminal probrain natriuretic peptide, and high sensitive C‐reactive protein (hs‐ CRP) as well as elevated occurrence of multivessel artery lesions. In addition, DM, SUA, hs‐ CRP, and multivessel artery lesions independently predicted high RASP risk. For restenosis, 21.0% patients occurred restenosis at 12 months after PCI, and patients in restenosis group presented with increased hypertension and DM occurrence, higher concentrations of SUA, LDL‐C, and hs‐ CRP, as well as longer target lesion and length of stent in surgery compared to nonrestenosis group. Also, DM, SUA, LDL‐C, hs‐ CRP, and length of target lesion independently predicted increased restenosis risk.

          Conclusion

          Diabetes mellitus, SUA, and hs‐ CRP are potential predictive factors for increased risk of both RASP and restenosis in CAD patients underwent PCI and drug‐eluting stents implantation.

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          Author and article information

          Contributors
          fuxianghua99@163.com
          Journal
          J Clin Lab Anal
          J. Clin. Lab. Anal
          10.1002/(ISSN)1098-2825
          JCLA
          Journal of Clinical Laboratory Analysis
          John Wiley and Sons Inc. (Hoboken )
          0887-8013
          1098-2825
          17 September 2018
          February 2019
          : 33
          : 2 ( doiID: 10.1002/jcla.2019.33.issue-2 )
          : e22666
          Affiliations
          [ 1 ] Department of Cardiology The Second Hospital of Hebei Medical University Shijiazhuang Hebei China
          Author notes
          [*] [* ] Correspondence

          Xianghua Fu, Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

          Email: fuxianghua99@ 123456163.com

          Author information
          http://orcid.org/0000-0003-4396-6991
          Article
          PMC6818547 PMC6818547 6818547 JCLA22666
          10.1002/jcla.22666
          6818547
          30221497
          a5e92732-4d81-4094-8bf3-1b2985b26f10
          © 2018 Wiley Periodicals, Inc.
          History
          : 04 July 2018
          : 09 August 2018
          : 10 August 2018
          Page count
          Figures: 1, Tables: 7, Pages: 13, Words: 8636
          Categories
          Research Article
          Research Article
          Custom metadata
          2.0
          jcla22666
          February 2019
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.7.0 mode:remove_FC converted:24.10.2019

          coronary artery disease,restenosis,drug‐eluting stents, RASP ,hs‐CRP

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