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      Inactivation of Endogenous Noradrenaline Released by Electrical Stimulation in vitro of Dog Saphenous Vein

      ,

      Journal of Vascular Research

      S. Karger AG

      Endogenous noradrenaline, Noradrenaline inactivation, Vein tissue, Oil immersion

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          Abstract

          The present investigation was undertaken to study the inactivation of endogenous noradrenaline (NA) released by electrical stimulation of the dog saphenous vein strips. Electrical stimulation of this preparation caused contractile responses which were due to release of NA. Relaxation curves were determined after oil immersion. Cocaine (10<sup>–5</sup> m) blocked the greatest part of the inactivation capacity showing that most of the released NA that acts on the α-adrenergic receptors is taken up by sympathetic nerves. Neither monoamine oxidase (MAO) nor catechol- O-methyl transferase (COMT) nor uptake<sub>2</sub> seem to play important roles in the inactivation of endogenous NA. After blockade of neuronal uptake by cocaine, both cortexone (6 × 10<sup>–5</sup> m), an inhibitor of uptake<sub>2</sub>, and U-0521 (10<sup>–4</sup> m) (3,4-dihydroxy-2-methyl propiophenone), an inhibitor of COMT, blocked a significant part of the remaining inactivation capacity showing that uptake<sub>2</sub> and COMT metabolism can represent an alternative to neuronal uptake. After cocaine, iproniazid (7 × 10<sup>–4</sup> m) was ineffective. The relative roles of the different mechanisms of inactivation of endogenous NA are different from those for exogenous NA in the dog saphenous vein strips.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1974
          1974
          18 September 2008
          : 11
          : 1-2
          : 45-54
          Affiliations
          Department of Pharmacology, Medical Faculty, Porto
          Article
          157998 Blood Vessels 1974;11:45–54
          10.1159/000157998
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Research Paper

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