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      Inertial focusing in microfluidics.

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          Abstract

          When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent decades learning why such behavior occurred, finally understanding that it was caused by previously unknown forces on particles in an inertial flow. The advent of microfluidics opened a new realm of possibilities for inertial focusing in the processing of biological fluids and cellular suspensions and created a field that is now rapidly expanding. Over the past five years, inertial focusing has enabled high-throughput, simple, and precise manipulation of bodily fluids for a myriad of applications in point-of-care and clinical diagnostics. This review describes the theoretical developments that have made the field of inertial focusing what it is today and presents the key applications that will make inertial focusing a mainstream technology in the future.

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          Author and article information

          Journal
          Annu Rev Biomed Eng
          Annual review of biomedical engineering
          1545-4274
          1523-9829
          Jul 11 2014
          : 16
          Affiliations
          [1 ] BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Boston, Massachusetts 02114; email: mtoner@hms.harvard.edu.
          Article
          NIHMS698101
          10.1146/annurev-bioeng-121813-120704
          4467210
          24905880
          a622fd32-90f9-4848-827f-e2032ba15de8
          History

          applied physics,biofluid processing,high throughput,hydrodynamic lift,label-free cell separation,particle separation

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