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      Homeostasis of eye growth and the question of myopia.

      1 ,
      Neuron
      Elsevier BV

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          Abstract

          As with other organs, the eye's growth is regulated by homeostatic control mechanisms. Unlike other organs, the eye relies on vision as a principal input to guide growth. In this review, we consider several implications of this visual guidance. First, we compare the regulation of eye growth to that of other organs. Second, we ask how the visual system derives signals that distinguish the blur of an eye too large from one too small. Third, we ask what cascade of chemical signals constitutes this growth control system. Finally, if the match between the length and optics of the eye is under homeostatic control, why do children so commonly develop myopia, and why does the myopia not limit itself? Long-neglected studies may provide an answer to this last question.

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          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          0896-6273
          0896-6273
          Aug 19 2004
          : 43
          : 4
          Affiliations
          [1 ] Department of Biology, City College of the City University of New York, New York, New York 10031, USA. jwallman@ccny.cuny.edu
          Article
          S0896627304004933
          10.1016/j.neuron.2004.08.008
          15312645
          a62aaa60-a661-4ea0-ae34-2df41690c47b
          History

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