+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      The Role of the Pituitary in Modifications of the Uterine Secretion of Spayed, Oestradiol-Primed Rats

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Tests performed on spayed, oestradiol-primed rats with ligated uteri and normal pituitary function have shown that treatment with sexual steroids modifies uterine secretion. Progesterone elicits a decrease in the quantity and an increase in the viscosity of the uterine secretion, an effect also produced by testosterone at very high dose levels. A decrease in the pH of the secretion was also observed. Supplementary oestradiol treatment was devoid of any activity.This paper describes the results obtained when the same experiment was carried out in normal castrate and castrate-hypophysectomized rats. The effects of varying subcutaneous doses of progesterone, testosterone, and oestradiol were compared. In both groups, a number of rats primed with oestradiol only served as controls.Progesterone induced a dose-dependent reduction in the weight of the uterus and in the quantity and pH of the uterine secretion, as well as a marked increase in its viscosity, in both intact and hypophysectomized rats.Testosterone increased the weight of the uterus and, when given in large doses, reduced the pH of both the lumen and secretion. The quantity of the uterine secretion diminished in response to high doses and its viscosity increased markedly only in rats bearing a pituitary.Oestradiol did not elicit significant changes in either group; a slight reduction in the pH of the uterine secretion was observed in response to high doses.It may be concluded that the progestative modifications induced by progesterone in the uterus of spayed, oestradiol-primed rats, including particularly changes in uterine secretion, are the effects of a peripheral mechanism not involving the pituitary. Testosterone appears to be an exception as far as the quantity and viscosity of uterine secretion are concerned, since modifications in these parameters are only observed in the presence of a functional pituitary body.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 4
          : 6
          : 367-375
          Research Department, Pharmaceutical Division, Ciba-Geigy Ltd., Basle
          178325 Horm Res 1973;4:367–375
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9


          Comment on this article