Cytotoxic Bryostatin Derivatives from the South China Sea Bryozoan Bugula neritina.

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Abstract

Four new macrocyclic lactones, bryostatin 21 (1) and 9-O-methylbryostatins 4, 16, and 17 (2-4), together with three known related compounds, bryostatins 4, 16, and 17 (5-7), have been isolated from an extract of the South China Sea bryozoan Bugula neritina. The structures of all compounds were unambiguously elucidated using detailed spectroscopic analysis. Structurally, the presence of a single methyl group at C-18 in compound 1 has not been observed before for known bryostatins. The isolated macrolides exhibited inhibitory effects against a small panel of human cancer cell lines.

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Journal

Journal ID (iso-abbrev): J. Nat. Prod.

Title: Journal of natural products

ISSN (Electronic): 1520-6025

ISSN (Print): 0163-3864

Publication date (Electronic): May 22 2015

Volume: 78

Issue: 5

Affiliations

[1 ] †Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People's Republic of China.

[2 ] ‡Marine Drugs Research Center, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai 200127, People's Republic of China.

Article

DOI: 10.1021/acs.jnatprod.5b00081

PubMed ID: 25932671

SO-VID: a6365232-92c3-4930-b943-f3962a4c8288

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