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      Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro

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          Abstract

          Romipeptides A and B ( 1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A ( 3), romidepsin ( 4) and valine-leucine dipeptide ( 5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis. Compounds 1–5 were evaluated for their anti-proliferative activities against three human cancer cell lines, SW620, HL60, and A549. The results showed most of these compounds exhibited antitumor activities in vitro, in which compound 2 displayed potent cytotoxicity to SW620, HL60 and A549 cell lines, with IC 50 of 12.5, 6.7 and 5.7 nmol·L −1, respectively.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2019
          : 17
          : 2
          : 155-160
          Affiliations
          1 State Key Lab of New Drug & Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200000, China
          Author notes
          *Corresponding author: HU Hai-Feng, E-mail: haifenghu88@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30018-4
          10.1016/S1875-5364(19)30018-4
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

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