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      Biochemical Characterization and Sex Dimorphism of Muscarinic Receptors in Rat Adenohypophysis

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          Abstract

          The ligand binding properties of muscarinic receptors present in rat adenohypophysis were studied using the tritiated antagonists N-methyl-4-piperidyl benzilate, 3-quinuclidinyl benzilate, and methylscopolamine. Equilibrium analysis of antagonists binding as well as competition experiments with several agonists were used to probe the nature of binding sites. The nature of antagonist binding in the adenohypophysis points to heterogeneity of binding sites, in contrast to other brain regions, in which homogeneous populations of muscarinic receptors were detected. Some of the binding properties, e.g. affinity constants, population of high affinity agonist binding sites, etc., clearly indicated differences between male and female rats as well as differences in female rats at various stages of estrous cycle. The nature of these receptors and their possible physiological role are discussed.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1981
          1981
          26 March 2008
          : 32
          : 5
          : 303-309
          Affiliations
          Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel
          Article
          123176 Neuroendocrinology 1981;32:303–309
          10.1159/000123176
          7195475
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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