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      Changes in Plasma Atrial Natriuretic Factor during Sequential Fluid Removal and Biochemical Correction in End-Stage Chronic Renal Failure Patients

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          Abstract

          Plasma immunoreactive atrial natriuretic factor (ANF) levels, their chromatographic profiles (high-performance liquid chromatography; HPLC) and changes during sequential ultrafiltration (UF; 1 litre/h) and biochemical correction without fluid removal (BC; 3 h) were studied in 8 end-stage chronic renal failure patients on intermittent haemodialysis ( > 1 year). Patients entered randomly the UF-BC or BC-UF protocols that were reversed after 1 week. HPLC showed a single peak of ANF immunoreactivity in plasma of end-stage chronic renal failure patients before dialysis sessions. ANF at the end of fluid removal fell by 31 ± 2% (p < 0.01) during UF-BC and by 30 ± 2% (p < 0.01) at the end of BC during BC-UF. In both sequences a further slight reduction in plasma ANF was observed during the second phase: it was 8.5 ± 5% (n.s.) during BC of the BC-UF and 12.5 ± 2% (p < 0.05) during fluid removal of BC-UF. Plasma ANF was not significantly removed by the machinery. BC did not modify the microhaematocrit in the BC-UF sequence while the microhaematocrit was significantly increased by UF (13 ± 1 and 14 ± 1%, p < 0.005 vs. basal, respectively), and decreased by BC in the UF-BC sequence (-5 ± 2% vs. end UF, p < 0.05). Serum creatinine and urea decreased significantly during BC in both protocols while they were unmodified during UF. No significant changes were seen in PRC during either protocol. Our results indicate that circulating levels of ANF in end-stage chronic renal failure patients, may be regulated by humoral factors in addition to the already well-known mechanisms such as plasma volume and right atrial pressure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1990
          1990
          10 December 2008
          : 55
          : 1
          : 58-62
          Affiliations
          aCentro Ipertensione, Università di Sassari, Italy; bMRC Blood Pressure Unit, Western Infirmary, Glasgow, UK
          Article
          185919 Nephron 1990;55:58–62
          10.1159/000185919
          2141110
          © 1990 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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