Journal ID (nlm-ta): Proc Natl Acad Sci U S A
Journal ID (iso-abbrev): Proc. Natl. Acad. Sci. U.S.A
Journal ID (hwp): pnas
Journal ID (pmc): pnas
Journal ID (publisher-id): PNAS
Title:
Proceedings of the National Academy of Sciences of the United States of America
Publisher:
National Academy of Sciences
ISSN
(Print):
0027-8424
ISSN
(Electronic):
1091-6490
Publication date
(Print):
26
March
2019
Publication date
(Electronic):
8
March
2019
Publication date PMC-release: 8
March
2019
Volume: 116
Issue: 13
Pages: 6101-6110
Affiliations
[1]
aIllawarra Health and Medical Research Institute , Wollongong, NSW 2522, Australia;
[2]
bSchool of Chemistry and Molecular Bioscience, University of Wollongong , Wollongong, NSW 2522, Australia;
[3]
cCentre for Misfolding Diseases, Department of Chemistry, University of Cambridge , CB2 1EW Cambridge, United Kingdom;
[4]
dCenter for Perinatal Research, The Research Institute at Nationwide Children’s Hospital , Columbus, OH 43205;
[5]
eSchool of Women’s and Children’s Health, University of New South Wales Medicine , Sydney, NSW 2052, Australia;
[6]
fThe George Institute for Global Health, University of New South Wales, Sydney , NSW 2052, Australia;
[7]
gWomen’s and Children’s Health, St. George Hospital , Kogarah, NSW 2217, Australia;
[8]
hSchool of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia;
[9]
iDepartment of Obstetrics and Gynecology, The Ohio State University College of Medicine , Columbus, OH 43210;
[10]
jNational Institute for Health Research, Cambridge Biomedical Research Centre , CB2 0QQ Cambridge, United Kingdom;
[11]
kDepartment of Obstetrics and Gynaecology, University of Cambridge , CB2 0SW Cambridge, United Kingdom;
[12]
lCentre for Trophoblast Research, University of Cambridge , CB2 0QQ Cambridge, United Kingdom;
[13]
mDepartment of Pediatrics, The Ohio State University College of Medicine , Columbus, OH 43210;
[14]
nDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine , Columbus, OH 43210;
[15]
oCollege of Medicine and Public Health, Flinders University , Bedford Park, SA 5042, Australia
Author notes
Edited by F. Ulrich Hartl, Max Planck Institute of Biochemistry, Martinsried, Germany,
and approved February 6, 2019 (received for review October 10, 2018)
Author contributions: J.H.C., I.A.B., and A.R.W. designed research; J.H.C., J.R.K.,
R.Z.A., G.Z., A.B.-G., M.C., C.S.B., I.A.B., and A.R.W. performed research; J.H.C.,
J.R.K., R.Z.A., G.Z., A.B.-G., A.H., W.W., M.C., B.S.F.G., M.L.T., M.R., C.S.B., D.S.C.-J.,
C.M.D., M.R.W., I.A.B., and A.R.W. analyzed data; J.H.C., J.R.K., C.M.D., M.R.W.,
I.A.B., and A.R.W. wrote the paper; and A.H., W.W., B.S.F.G., M.L.T., and D.S.C.-J.
coordinated the collection of blood plasma and clinical information used in this study.
1Present address: Department of Obstetrics and Gynecology, University of Illinois at
Chicago College of Medicine, Chicago, IL 60612.
2Present addresses: School of Biomedical Sciences and Pharmacy, Faculty of Health and
Medicine, University of Newcastle, Callaghan, NSW 2308, Australia and Priority Research
Centre for Cancer Research, Innovation & Translation, Faculty of Health & Medicine,
Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
Author information
Article
Publisher ID:
201817298
DOI: 10.1073/pnas.1817298116
PMC ID: 6442606
PubMed ID: 30850528
SO-VID: a6808876-5c4d-4018-8008-252f48535702
Copyright © Copyright © 2019 the Author(s). Published by PNAS.
Funded by: Department of Health | National Health and Medical Research Council (NHMRC)
501100000925
Award ID: APP1099991
Award Recipient
: Amanda Henry
Award Recipient
: Amy R Wyatt
Funded by: Faculty of Science, Medicine and Public Health, University of Wollongong
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Centre for Medical and Molecular Biosciences
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Australian Institute of Nuclear Science and Engineering (AINSE)
501100001023
Award ID: N/A
Award Recipient
: Jordan H Cater
Funded by: Commonwealth Government of Australia
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Illawarra Health and Medical Research Institute
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Eunice Kennedy Shriver National Institute of Child Health and Human Development
Award ID: RO1 HD 04732
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Cambridge Centre for Misfolding Diseases
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Wellcome Trust Programme Grant
Award ID: 094425/Z/10/Z
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: NIHR Cambridge Comprehensive Biomedical Research Centre
Award ID: N/A
Award Recipient
: Jordan H Cater
Award Recipient
: Janet R Kumita
Award Recipient
: Ana Bernardo-Gancedo
Award Recipient
: Brin S. F. Grenyer
Award Recipient
: Michelle L Townsend
Award Recipient
: Marie Ranson
Award Recipient
: D. Stephen Charnock-Jones
Award Recipient
: Christopher M. Dobson
Award Recipient
: Mark R. Wilson
Award Recipient
: Irina A Buhimschi
Award Recipient
: Amy R Wyatt
Funded by: Department of Health | National Health and Medical Research Council (NHMRC)
501100000925
Award ID: APP1141570
Award Recipient
: Amanda Henry
Award Recipient
: Amy R Wyatt