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      Laser flare-cell photometer: principle and significance in clinical and basic ophthalmology.

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          Abstract

          A slit-lamp examination is an indispensable and essential clinical evaluation method in ophthalmology, but, it is qualitative subjective. To complement its weaknesses in making a quantitative evaluation of flare intensity and number of cells in the aqueous humor in the eye, we invented the laser flare-cell photometer in 1988. The instrument enables a non-invasive quantitative evaluation of flare intensity and number of cells in the aqueous with good accuracy and repeatability as well as maneuverability equal to slit-lamp microscopy. The instrument can elucidate the pathophysiology in the blood-aqueous barrier (BAB) function in a variety of ocular disorders. The accuracy of the instrument makes it possible to investigate not only the pathophysiology of intraocular disorders but also the effects of various drugs and surgical procedures in BAB. The instrument does not only lighten the burden on patients in clinical examinations and study but it also helps minimize the sacrifice of experimental animals and improves the reliability of the results by minimizing inter-individual variations through its good repeatability. Here I shall relate how the instrument has been applied to clinical and basic studies in ophthalmology and what novel knowledge its application contributed to pathophysiology in ophthalmology.

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          Author and article information

          Journal
          Jpn J Ophthalmol
          Japanese journal of ophthalmology
          Springer Science and Business Media LLC
          1613-2246
          0021-5155
          Jan 2017
          : 61
          : 1
          Affiliations
          [1 ] Public Interest Incorporated Foundation Isshinkai, 3-37-8 Hongo, Bunkyo, Tokyo, 113-0033, Japan. sawamtr@ivy.ocn.ne.jp.
          [2 ] Emeritus Professor, Nihon University, Tokyo, Japan. sawamtr@ivy.ocn.ne.jp.
          Article
          10.1007/s10384-016-0488-3
          10.1007/s10384-016-0488-3
          27888376
          a690cfae-fc6c-4b3c-a846-eb92b3fe1bda
          History

          Blood-aqueous barrier,Flare-cell photometer,Intraocular inflammation,Pathophysiology,Quantitative assessment

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