Constantina Bakolitsa a , b , Abhinav Kumar a , c , Dennis Carlton a , d , Mitchell D. Miller a , c , S. Sri Krishna a , b , e , Polat Abdubek a , f , Tamara Astakhova a , e , Herbert L. Axelrod a , c , Hsiu-Ju Chiu a , c , Thomas Clayton a , d , Marc C. Deller a , d , Lian Duan a , e , Marc-André Elsliger a , d , Julie Feuerhelm a , f , Slawomir K. Grzechnik a , e , Joanna C. Grant a , f , Gye Won Han a , d , Lukasz Jaroszewski a , b , e , Kevin K. Jin a , c , Heath E. Klock a , f , Mark W. Knuth a , f , Piotr Kozbial a , b , David Marciano a , d , Daniel McMullan a , f , Andrew T. Morse a , e , Edward Nigoghossian a , f , Linda Okach a , f , Silvya Oommachen a , c , Jessica Paulsen a , f , Ron Reyes a , c , Christopher L. Rife a , c , Henry J. Tien a , d , Christina V. Trout a , d , Henry van den Bedem a , c , Dana Weekes a , b , Qingping Xu a , c , Keith O. Hodgson a , g , John Wooley a , e , Ashley M. Deacon a , c , Adam Godzik a , b , e , Scott A. Lesley a , d , f , Ian A. Wilson a , d , *
27 October 2009
Joint Center for Structural Genomics (JCSG) special issue
The first structural representative of the PF08866 (DUF1831) protein family reveals a potential new α+β fold and indicates a possible involvement in amino-acid metabolism.
The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.