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      Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism

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      Acta Crystallographica Section F: Structural Biology and Crystallization Communications

      International Union of Crystallography

      Joint Center for Structural Genomics (JCSG) special issue

      structural genomics, DUFs, S-adenosylmethionine decarboxylase, amino-acid metabolism, probiotics

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          Abstract

          The first structural representative of the PF08866 (DUF1831) protein family reveals a potential new α+β fold and indicates a possible involvement in amino-acid metabolism.

          Abstract

          The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.

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          Author and article information

          Conference
          Acta Crystallogr Sect F Struct Biol Cryst Commun
          Acta Cryst. F
          Acta Crystallographica Section F: Structural Biology and Crystallization Communications
          International Union of Crystallography
          1744-3091
          1 October 2010
          27 October 2009
          27 October 2009
          : 66
          : Pt 10 ( publisher-idID: f101000 )
          : 1205-1210
          Affiliations
          [a ]Joint Center for Structural Genomics, http://www.jcsg.org, USA
          [b ]Program on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, CA, USA
          [c ]Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA
          [d ]Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
          [e ]Center for Research in Biological Systems, University of California, San Diego, La Jolla, CA, USA
          [f ]Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA
          [g ]Photon Science, SLAC National Accelerator Laboratory, Menlo Park, CA, USA
          Author notes
          Correspondence e-mail: wilson@ 123456scripps.edu
          Article
          wd5114 ACSFCL S1744309109023689
          10.1107/S1744309109023689
          2954206
          20944212
          © Bakolitsa et al. 2010

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          Joint Center for Structural Genomics (JCSG) special issue
          Categories
          New Folds

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