Sustained Local Release of Methylprednisolone From a Thiol-Acrylate Poly(Ethylene Glycol) Hydrogel for Treating Chronic Compressive Radicular Pain.

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Abstract

A preclinical animal model of chronic ligation of the sciatic nerve was used to compare the effectiveness of a slow-release hydrogel carrying methylprednisolone to methylprednisolone injection alone, which simulates the current standard of care for chronic compressive radiculopathy (CR).

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Journal

Journal ID (iso-abbrev): Spine

Title: Spine

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1528-1159

ISSN (Print): 0362-2436

Publication date (Electronic): Apr 2016

Volume: 41

Issue: 8

Affiliations

[1 ] *Department of Neurosurgery, Geisinger Clinic, Danville, PA †InVivo Therapeutics Corporation, Cambridge, MA ‡Laboratory of Molecular Neuroscience and Neurooncology, Geisinger Clinic, Danville, PA §Department of Neurosurgery, New England Baptist Hospital, Boston, MA ¶David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA ||Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.

Article

DOI: 10.1097/BRS.0000000000001309

PubMed ID: 26630427

SO-VID: a69aa6ee-7345-4ce6-884e-05a7169a1b6f

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