Tension, contraction and tissue morphogenesis

Abstract

<p class="first" id="d4083221e119">D'Arcy Thompson was a proponent of applying mathematical and physical principles to biological systems, an approach that is becoming increasingly common in developmental biology. Indeed, the recent integration of quantitative experimental data, force measurements and mathematical modeling has changed our understanding of morphogenesis – the shaping of an organism during development. Emerging evidence suggests that the subcellular organization of contractile cytoskeletal networks plays a key role in force generation, while on the tissue level the spatial organization of forces determines the morphogenetic output. Inspired by D'Arcy Thompson's <i>On Growth and Form</i>, we review our current understanding of how biological forms are created and maintained by the generation and organization of contractile forces at the cell and tissue levels. We focus on recent advances in our understanding of how cells actively sculpt tissues and how forces are involved in specific morphogenetic processes. </p><p class="first" id="d4083221e125"> <b>Summary:</b> This Review emphasizes the role of the actomyosin meshwork in determining the forces that operate within and between cells and their environment to shape and organize cells and tissues. </p>