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      The Diagnosis of Acute Renal Failure

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      Nephron

      S. Karger AG

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          Abstract

          The urine/plasma osmolality ratio was examined in 13 patients with acute incipient or functional renal failure, who had oliguria, a raised blood urea and a positive response to mannitol, and in 12 patients with acute organic renal failure (acute tubular necrosis) with oliguria, a high blood urea and no response to mannitol. In the former the mean ratio was 1.35 with a standard error of the mean of 0.053, and in the latter it was 1.035 with a standard error of the mean of 0.032. The difference between the two conditions was statistically significant. There was no overlap. The urine/plasma osmolality ratio was found to be an accurate test for the early diagnosis of the type of acute renal failure. It can serve as a good guide for the selection of the patients where mannitol therapy is necessary as in incipient renal failure, from those where mannitol is useless or even harmful, as in acute tubular necrosis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1965
          1965
          25 November 2008
          : 2
          : 5
          : 287-295
          Affiliations
          Nephrology Unit, Tel-Hashomer Government Hospital, Tel-Hashomer, Israel
          Article
          179411 Nephron 1965;2:287–295
          10.1159/000179411
          © 1965 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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