There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Mononuclear phagocytes are versatile cells that can express different functional programs
in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively
activated) macrophages are the extremes of a continuum of functional states. Macrophages
that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines
to acquire a polarized M2 phenotype. These functionally polarized cells, and similarly
oriented or immature dendritic cells present in tumors, have a key role in subversion
of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.