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      Dialysis-Associated Arthropathy: Secondary Ion Mass Spectrometry Evidence of Aluminum Silicate in β 2-MicroglobuIin Amyloid Synovial Tissue and Articular Cartilage

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          Abstract

          The role of aluminum accumulation in articular tissues of patients affected by dialysis-associated arthropathy (DAA) is questioned. The aim of this work is to identify the nature of these aluminum accumulations by the use of secondary ion mass spectrometry (SIMS). Al/Si ratios of about 1, measured by SIMS, strongly suggest for the first time the presence of aluminum silicates and possibly aluminum hydroxides in amyloid synovial tissue and articular cartilage of 1 patient with DAA and aluminum intoxication. This is thermodynamically consistent with the total dissolved Al and Si contents and pH measured in the synovial fluids. These results are similar to the abnormal Al distribution recently found by SIMS in the forebrain of chronic renal dialysis patients and to the amorphous aluminum silicates identified in the core of senile plaques in Alzheimer’s disease.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 65
          : 4
          : 559-563
          Affiliations
          aCRPG-CNRS, bURA CNRS 1288 ‘Physiopathologie et Pharmacologie Articulaire’, et cLaboratoire d’Histologie (RCP No. 080785), Faculté de Médecine, Vandœuvre-les-Nancy; dCentre Edouard Rist, Paris; eENS Lyon, Laboratoire de Géologie, Lyon, France
          Article
          187563 Nephron 1993;65:559–563
          10.1159/000187563
          8302409
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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