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      Dependency of Premature Ventricular Contractions on Heart Rate and Circadian Rhythms during Childhood

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          The aim of the present study was to identify and quantify the rate dependence of premature ventricular contractions (PVC) during childhood. A 24-hour Holter recording was performed in 16 consecutive children, aged 22 days to 11 years (mean age 5.6 years), with frequent (>5,000/day), isolated monomorphic PVC. Those PVC were identified and the length of the preceding sinus cycle was measured. The values were ordered into 50-ms class intervals, and the percentage of PVC for each class was calculated and then analyzed by linear regression analysis. On the basis of the significance of the p value, and the positive or negative value of the slope, we identified a tachycardia-enhanced, a bradycardia-enhanced, and an indifferent pattern. Chronobiologic analysis was made by the cosinor method. All the patients had upper and lower limits of cycle length beyond which PVC disappeared. A tachycardia-enhanced pattern was present in 7 patients and an indifferent one in 9 patients. In the latter a second-degree polynomial correlation was systematically found. Children but not infants had a significant circadian variation in the frequency of PVC with a very variable time of highest incidence. In conclusion, it is possible to identify a circadian rhythm of PVC and a spontaneous trend between their incidence and the length of the preceding cardiac cycle in children.

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          Most cited references 1

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          Circadian variations of plasma catecholamine, cortisol and immunoreactive insulin concentrations in supine subjects

           M.B. Turton,  T Deegan (1974)

            Author and article information

            S. Karger AG
            June 2000
            04 July 2000
            : 93
            : 1-2
            : 70-73
            Division of Pediatric Cardiology, aCHR Citadelle and bMathematical Institute, University of Liège, Belgium
            7004 Cardiology 2000;93:70–73
            © 2000 S. Karger AG, Basel

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            Page count
            Figures: 3, Tables: 2, References: 20, Pages: 4
            Arrhythmias, Electrophysiology and Electrocardiography


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