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      Effect of Intraventricular Noradrenaline and Acetylcholine on Plasma Unesterified Fatty Acid Concentration in Sheep

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          Abstract

          Noradrenaline (3 µg/kg) injected into a lateral cerebral ventricle of sheep exposed to –15 °C caused a fall in plasma unesterified fatty acid (UFA) concentration. Acetylcholine with eserine (5 µg/kg of each) similarly injected in sheep at an environment of +5°C resulted in an increase in plasma UFA concentration. Intravenous injections of bethanidine, an adrenergic neurone blocking agent, did not prevent a marked increase in plasma UFA concentration after intraventricular acetylcholine and eserine. Denervating the adrenal medullae by cutting the right and the left splanchnic nerves also did not prevent a response to intraventricular acetylcholine and eserine. The combined effect of bethanidine and cutting the splanchnic nerves almost completely blocked the response to intraventricular acetylcholine and eserine. These results indicate that acetylcholine and noradrenaline may be the central neurotransmitter substances controlling plasma UFA concentration through the activity of the sympathetic nerves and splanchnic nerves, and this may be important for the increased heat production of sheep during cold exposure.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 9
          : 6
          : 365-374
          Affiliations
          Department of Physiology, Hannah Research Institute, Ayr
          Article
          122069 Neuroendocrinology 1972;9:365–374
          10.1159/000122069
          5037211
          a6e5c26e-5f71-4825-8bac-7b7ba27ec5bd
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 19 November 1971
          : 04 February 1972
          Page count
          Pages: 10
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Central transmitter substances,Acetylcholine,Noradrenaline,Plasma unesterified fatty acids

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