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      Low Urinary Albumin Excretion in Astronauts during Space Missions

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          Abstract

          Background: Physiological changes occur in man during space missions also at the renal level. Proteinuria was hypothesized for space missions but research data are missing. Methods: Urinary albumin, as an index of proteinuria, and other variables were analyzed in 4 astronauts during space missions onboard the MIR station and on the ground (control). Mission duration before first urine collection in the four astronauts was 4, 26, 26, and 106 days, respectively. On the ground, data were collected 2 months before mission in two astronauts, 6 months after in the other astronauts. A total of twenty-two 24-hour urine collections were obtained in space (n per astronaut = 1–14) and on the ground (n per astronaut = 2–12). Urinary albumin was measured by radioimmunoassay. For each astronaut, mean of data in space and on the ground was defined as individual average. Results: The individual averages of 24 h urinary albumin were lower in space than on the ground in all astronauts; the difference was significant (mean ± SD, space and on the ground = 3.41 ± 0.56 and 4.70 ± 1.20 mg/24 h, p = 0.017). Dietary protein intake and 24-hour urinary urea were not significantly different between space and on the ground. Conclusions: Urinary albumin excretion is low during space mission compared to data on the ground before or after mission. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity).

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          Microalbuminuria in Nondiabetic Adults

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            Unexpected renal responses in space

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              Author and article information

              Journal
              NEP
              Nephron Physiol
              10.1159/issn.1660-2137
              Nephron Physiology
              S. Karger AG
              1660-2137
              2003
              April 2003
              09 May 2003
              : 93
              : 4
              : p102-p105
              Affiliations
              aNephrology – Second University of Naples, Naples, Italy; bDLR – Aerospace Medicine, Cologne, Germany; cAviation Medicine – National University Hospital, Copenaghen, Denmark; dEuropean Space Agency, Noordwijk, The Netherlands; eCentro Gamma, Montesarchio, Italy; fMedical Faculty, University (RWTH) Aachen, Germany
              Article
              70243 Nephron Physiol 2003;93:p102–p105
              10.1159/000070243
              12759571
              © 2003 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Tables: 1, References: 16, Pages: 1
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/70243
              Categories
              Preliminary Communication

              Cardiovascular Medicine, Nephrology

              Microalbuminuria, Gravity, Kidney

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