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      The interplay between cell signalling and the mevalonate pathway in cancer.

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          Abstract

          The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.

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          Author and article information

          Journal
          Nat. Rev. Cancer
          Nature reviews. Cancer
          Springer Nature
          1474-1768
          1474-175X
          November 2016
          : 16
          : 11
          Affiliations
          [1 ] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.
          [2 ] Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.
          [3 ] Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2.
          Article
          nrc.2016.76
          10.1038/nrc.2016.76
          27562463
          a6f9889c-cfbf-4ef2-9d19-a97a1a78ac85
          History

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