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      Reduction of Estradiol-Binding Capacity of Neural Target Tissues in Light-Sterilized Rats

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          Abstract

          Estradiol-binding capacity of the hypo-thalamus and parietal cortex, measured with tritiated estradiol, has been found to be significantly reduced in rats made anovulatory by exposure to continuous illumination when compared to controls of approximately equal weight maintained in a light-controlled (14 h light and 10 h dark) room. This finding suggests that constant light interferes with the normal replacement of estradiol-binding proteins in the brain. The decrease of the hypothalamic estrogen-receptors might account for the loss of the positive neurohormonal estrogen feedback inducing ovulatory LH release in the rat.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 14
          : 3-4
          : 187-194
          Affiliations
          Department of Anatomy, University Medical School, Pécs
          Article
          122258 Neuroendocrinology 1974;14:187–194
          10.1159/000122258
          4859466
          a713cfdb-159e-42f1-a709-425c3dde20b2
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 09 July 1973
          : 27 September 1973
          Page count
          Pages: 8
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Hypothalamus,Estradiol-binding capacity,Continuous illumination,Ovulation

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