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      Reduction of Estradiol-Binding Capacity of Neural Target Tissues in Light-Sterilized Rats

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          Abstract

          Estradiol-binding capacity of the hypo-thalamus and parietal cortex, measured with tritiated estradiol, has been found to be significantly reduced in rats made anovulatory by exposure to continuous illumination when compared to controls of approximately equal weight maintained in a light-controlled (14 h light and 10 h dark) room. This finding suggests that constant light interferes with the normal replacement of estradiol-binding proteins in the brain. The decrease of the hypothalamic estrogen-receptors might account for the loss of the positive neurohormonal estrogen feedback inducing ovulatory LH release in the rat.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 14
          : 3-4
          : 187-194
          Affiliations
          Department of Anatomy, University Medical School, Pécs
          Article
          122258 Neuroendocrinology 1974;14:187–194
          10.1159/000122258
          4859466
          © 1974 S. Karger AG, Basel

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          Pages: 8
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