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      Involvement of neuronal, inducible and endothelial nitric oxide synthases in capsaicin-induced muscle hypersensitivity

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          Abstract

          Nitric oxide, which has been implicated in the development of hyperalgesia in the spinal system, has not been systematically studied in the trigeminal system, especially in the context of inflammatory muscle pain condition. In this study, we investigated the functional role of centrally released nitric oxide in the pathogenesis of orofacial muscle pain. Specifically, we examined the contribution of neuronal, inducible and endothelial nitric oxide synthases, nNOS, iNOS and eNOS, respectively, in mediating masseter hypersensitivity under acute inflammatory condition. Time-dependent changes in nNOS, iNOS and eNOS protein expression in the subnucleus caudalis (Vc) were assessed following capsaicin injection in the masseter muscle of male Sprague Dawley rats. The expression of all three nitric oxide synthases was significantly up-regulated 30–60 min following capsaicin stimulation, which paralleled the time course of the development of capsaicin-induced masseter hypersensitivity. Pretreatment with each NOS inhibitor significantly attenuated the masseter hypersensitivity. These data showed that all three NOS in the Vc are functionally important for the development of craniofacial muscle hyperalgesia and suggest that the three NOS are closely orchestrated to regulate the level of nitric oxide under normal and pathologic conditions.

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          Author and article information

          Journal
          9801774
          21642
          Eur J Pain
          Eur J Pain
          European journal of pain (London, England)
          1090-3801
          1532-2149
          13 February 2021
          11 December 2008
          October 2009
          26 February 2021
          : 13
          : 9
          : 924-928
          Affiliations
          Department of Neural and Pain Sciences, University of Maryland Baltimore, School of Dentistry, 650 W. Baltimore St., Baltimore, MD 21201, USA
          Author notes
          [* ]Corresponding author. Tel.: +1 410 706 6027; fax: +1 410 706 0865. jro@ 123456umaryland.edu (J.Y. Ro).
          Article
          PMC7909680 PMC7909680 7909680 nihpa1672513
          10.1016/j.ejpain.2008.11.009
          7909680
          19084437
          a7307538-3a2f-4c0e-8c07-3b723e2b7f6e
          History
          Categories
          Article

          Capsaicin,Nitric oxide synthases,Rat,Muscle pain,Trigeminal
          Capsaicin, Nitric oxide synthases, Rat, Muscle pain, Trigeminal

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