30
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      An essential role for ectodomain shedding in mammalian development.

      Science (New York, N.Y.)
      ADAM Proteins, Amino Acid Sequence, Animals, Catalytic Domain, Cell Membrane, metabolism, Cells, Cultured, Crosses, Genetic, Embryonic and Fetal Development, L-Selectin, Ligands, Membrane Proteins, Metalloendopeptidases, chemistry, genetics, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Mutation, Phenotype, Protein Processing, Post-Translational, Receptors, Tumor Necrosis Factor, Transforming Growth Factor alpha, Tumor Necrosis Factor-alpha

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.

          Related collections

          Author and article information

          Comments

          Comment on this article