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      Coordinate Expression of Hypothalamic Pro-Dynorphin and Pro-Vasopressin mRNAs with Osmotic Stimulation

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          Abstract

          Peptides derived from pro-dynorphin and pro-vasopressin precursors coexist within neurosecretory vesicles of magnocellular neurons in the rat hypothalamus projecting to the posterior pituitary. The secretory activity of these neurons can be stimulated using physiological manipulations known to increase plasma vasopressin levels, such as dehydration and salt-loading. With chronic osmotic challenge, the mRNAs for both pro-dynorphin and pro-vasopressin increase in parallel in the supraoptic and paraventricular nuclei of the hypothalamus, but not within the nonmagnocellular suprachiasmatic nucleus cell groups projecting elsewhere than the neural lobe. The results indicate an example of coordinate regulation of mRNA expression for coexisting peptides within the brain.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1986
          1986
          01 April 2008
          : 44
          : 2
          : 222-228
          Affiliations
          aMental Health Research Institute, University of Michigan, Ann Arbor, Mich., and bInstitute for Advanced Biomedical Research, Oregon Health Sciences University, Portland, Oreg., USA
          Article
          124649 Neuroendocrinology 1986;44:222–228
          10.1159/000124649
          2432438
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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