Growth hormone therapy in short-stature patients with kyphoscoliosis: a literature review

Abstract

• The aim of the study was to conduct a literature review on growth hormone therapy in short-stature patients with kyphoscoliosis.

• The search strategy was performed in which all the relevant papers published in 20 years were included on Pub Med, Central, and Google scholar by using keywords short stature, growth hormones, adverse events of growth hormones in kyphoscoliosis, safety.

• The study investigation supports the idea that giving human growth hormone (HGH) to a diverse population of short-statured children does not enhance the occurrence of scoliosis.

• Patients on HGH therapy for progressing scoliosis had syndromes in which scoliosis was more prevalent in an age-matched group. Short stature attributed to progressive growth failure is prevalent in all mucopolysaccharidosis (MPS) disorders, as per the existing research on growth and growth hormone in MPS.

• MPS should be explored in children who are being tested for short stature since growth failure might be the presenting symptom.