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      Risk Factors and Mortality of COVID-19 in Patients With Lymphoma: A Multicenter Study


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          Patients with cancer are poorly represented in coronavirus disease 2019 (COVID-19) series, and heterogeneous series concerning hematology patients have been published. This study aimed to analyze the impact of COVID-19 in patients with lymphoma. We present a multicenter retrospective study from 19 centers in Madrid, Spain, evaluating risk factors for mortality in adult patients with COVID-19 and lymphoma. About 177 patients (55.9% male) were included with a median follow-up of 27 days and a median age of 70 years. At the time of COVID-19 diagnosis, 49.7% of patients were on active treatment. The overall mortality rate was 34.5%. Age >70 years, confusion, urea concentration, respiratory rate, blood pressure, and age >65 score ≥2, heart disease, and chronic kidney disease were associated with higher mortality risk ( P < 0.05). Active disease significantly increased the risk of death (hazard ratio, 2.43; 95% confidence interval, 1.23-4.77; P = 0.01). However, active treatment did not modify mortality risk and no differences were found between the different therapeutic regimens. The persistence of severe acute respiratory syndrome coronavirus 2-positive polymerase chain reaction after week 6 was significantly associated with mortality (54.5% versus 1.4%; P < 0.001). We confirm an increased mortality compared with the general population. In view of our results, any interruption or delay in the start of treatment should be questioned given that active treatment has not been demonstrated to increase mortality risk and that achieving disease remission could lead to better outcomes.

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

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              Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

              There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).

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                Lippincott Williams & Wilkins (Philadelphia, PA )
                March 2021
                10 February 2021
                : 5
                : 3
                [1 ]Hospital General Universitario Gregorio Marañón, Madrid, Spain
                [2 ]Hospital Universitario 12 de octubre, Madrid, Spain
                [3 ]Hospital Universitario Infanta Leonor, Madrid, Spain
                [4 ]Hospital Universitario Puerta de Hierro, Madrid, Spain
                [5 ]Hospital Universitario Moncloa, Madrid, Spain
                [6 ]Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain
                [7 ]Hospital Universitario Fundación Alcorcón, Madrid, Spain
                [8 ]Hospital Universitario de La Princesa, Madrid, Spain
                [9 ]Hospital Clínico San Carlos, Madrid, Spain
                [10 ]Hospital Universitario de Móstoles, Madrid, Spain
                [11 ]Hospital Universitario Severo Ochoa, Madrid, Spain
                [12 ]Hospital Universitario Rey Juan Carlos, Madrid, Spain
                [13 ]Hospital Universitario General de Villalba, Madrid, Spain
                [14 ]Hospital Universitario de Getafe, Madrid, Spain
                [15 ]Hospital Universitario del Sureste, Madrid, Spain
                [16 ]Hospital Universitario Ramón y Cajal, Madrid, Spain
                [17 ]Hospital Central de la Defensa Gómez Ulla, Madrid, Spain
                [18 ]Hospital Universitario Infanta Sofía, Madrid, Spain
                [19 ]Hospital Universitario Príncipe de Asturias, Madrid, Spain
                [20 ]Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
                Author notes
                Correspondence: Mariana Bastos-Oreiro ( marianabeatriz.bastos@ 123456salud.madrid.org ).
                Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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